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116539-56-1

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116539-56-1 Usage

Uses

1-β-Hydroxy-1-(2-thienyl)-3-methylaminopropane is an intermediate in the synthesis of Duloxetine (D721000) derivatives.

Check Digit Verification of cas no

The CAS Registry Mumber 116539-56-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,5,3 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 116539-56:
(8*1)+(7*1)+(6*6)+(5*5)+(4*3)+(3*9)+(2*5)+(1*6)=131
131 % 10 = 1
So 116539-56-1 is a valid CAS Registry Number.

116539-56-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(methylamino)-1-thiophen-2-ylpropan-1-ol

1.2 Other means of identification

Product number -
Other names 3-Methylamino-1-thiophen-2-yl-propan-1-ol 1HCl salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:116539-56-1 SDS

116539-56-1Relevant articles and documents

OLIGOMER-ARYLOXY-SUBSTITUTED PROPANAMINE CONJUGATES

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Paragraph 0256; 0260, (2016/11/17)

The invention relates to (among other things) oligomer- aryloxy-substituted propanamine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated aryloxy-substituted propanamine compounds.

Total synthesis of fluoxetine and duloxetine through an in situ imine formation/borylation/transimination and reduction approach

Calow, Adam D. J.,Fernandez, Elena,Whiting, Andrew

, p. 6121 - 6127 (2014/08/05)

We report efficient, catalytic, asymmetric total syntheses of both (R)-fluoxetine and (S)-duloxetine from α,β-unsaturated aldehydes conducting five sequential one-pot steps (imine formation/copper mediated β-borylation/transimination/reduction/oxidation) followed by the specific ether group formation which deliver the desired products (R)-fluoxetine in 45% yield (96% ee) and (S)-duloxetine in 47% yield (94% ee). This journal is the Partner Organisations 2014.

5-Phenylthio-1,3-oxazinan-4-ones via hetero Diels-Alder reactions: synthesis of (R)- and (S)-Duloxetines and Fluoxetines

Panunzio, Mauro,Tamanini, Emiliano,Bandini, Elisa,Campana, Eileen,D'Aurizio, Antonio,Vicennati, Paola

, p. 12270 - 12280 (2007/10/03)

The synthesis of 5-phenylthio-1,3-oxazinan-4-ones, through a hetero Diels-Alder strategy, is described. The cycloadducts thus prepared have been shown to be useful intermediates for the synthesis of 1,3-aminoalcohols, valuable intermediates in the preparation of biologically significant molecules, e.g., optically active Duloxetines and Fluoxetines. In the course of this elaboration a novel microwave assisted desulfurization reaction is reported.

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