116545-98-3Relevant academic research and scientific papers
1,3,8-Trisubstituted xanthines. Effect of substitution pattern upon adenosine receptor A1/A2 affinity
Erickson, Ronald H.,Hiner, Roger N.,Feeney, Scott W.,Blake, Paul R.,Rzeszotarski, Waclaw J.,et al.
, p. 1431 - 1435 (2007/10/02)
A series of 11,8-substituted xanthines having three different substitution patterns on the 1- and 3-positions was prepared.These compounds were assessed for
8-arylxanthines
-
, (2008/06/13)
1,3-alkylsubstituted-8-(3,4-,3- or 4-substituted phenyl)xanthines and pharmaceutically acceptable salts of such compounds are disclosed. The 3-substituents are hydrogen, dimethylaminomethyl, or 2,3-dihydroxypropyloxy. The 4-substituents are selected from hydroxy, cyano, --NHCON(R 5) 2, --C( NH)N(R 5) 2, --NH--C( NH)N(R 5) 2, with each R 5 independently being hydrogen or an alkyl group of one to three carbons and provided that when the 3-substituent is hydrogen the 4-substituent is not hydroxy or hydrogen.The compounds are potent adenosine receptor antagonists having relatively low lipophilicity. The compounds are intended for use as bronchodilators and cardiotonics.
