116546-78-2

Upstream product

• 79027-28-4 (2S)-3-(benzyloxy)-2-methylpropanal 
• 925-90-6 ethylmagnesium bromide 
• 116652-76-7 Weinreb amide of (S)-3-benzyloxy-2-methylpropionic acid 
• 74924-27-9 methyl (S)-3-benzyloxy-2-methylpropanoate 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 

Downstream Products

• 116661-42-8 (1R,2R,4S)-5-Benzyloxy-1-furan-2-yl-1-hydroxy-2,4-dimethyl-pentan-3-one 
• 116546-81-7 (1S,2S,4S)-5-Benzyloxy-1-furan-2-yl-1-hydroxy-2,4-dimethyl-pentan-3-one 
• 160796-65-6 (2S,4R,5R,6E)-1-(benzyloxy)-5-hydroxy-2,4-dimethyl-6-octen-3-one 
• 160796-66-7 (2S,4R,5S,6E)-1-(benzyloxy)-5-hydroxy-2,4-dimethyl-6-octen-3-one 
• 141611-63-4 (2S,4S,5R,6E)-1-(benzyloxy)-5-hydroxy-2,4-dimethyl-6-octen-3-one 
• 116546-79-3 (2S,4S,5S,6E)-1-(benzyloxy)-5-hydroxy-2,4-dimethyl-6-octen-3-one 
• 140925-38-8 (2S,4S,5R)-1-benzyloxy-5-hydroxy-2,4,6-trimethylhept-6-en-3-one 
• 116661-41-7 (2S,4R,5R)-1-(benzyloxy)-5-hydroxy-2,4,6-trimethylhept-6-en-3-one 
• 116661-40-6 (2S,4S,5S)-1-(benzyloxy)-5-hydroxy-2,4,6-trimethyl-6-hepten-3-one 
• 116546-80-6 (2S,4R,5S)-1-Benzyloxy-5-hydroxy-2,4-dimethyl-hexan-3-one 
• 116546-80-6 (2S,4S,5R)-1-Benzyloxy-5-hydroxy-2,4-dimethyl-hexan-3-one 
• 128146-27-0 (2S,4R,5R)-1-Benzyloxy-5-hydroxy-2,4-dimethyl-octan-3-one 
• 128146-27-0 (2S,4R,5S)-1-Benzyloxy-5-hydroxy-2,4-dimethyl-octan-3-one 
• 128146-27-0 (2S,4S,5R)-1-Benzyloxy-5-hydroxy-2,4-dimethyl-octan-3-one 

Relevant academic research and scientific papers

A practical synthesis of (+)-discodermolide and analogues: Fragment union by complex aldol reactions

A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in 10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the C1-C6 (7), C9-C16 (8), and Csub

Versatile enantioselective synthesis of four diastereomers of serricornin, a sex pheromone of the cigarette beetle, using the SAMP/RAMP-hydrazone method

Serricornin is a female-produced sex pheromone of the cigarette beetle (Lasioderma serricorne), which is a pest of dried foodstuffs and tobacco. We report a versatile and short synthesis of all possible 6,7-syn-isomers of serricornin, including the natura

The total synthesis of swinholide A. Part 1 : A stereocontrolled synthesis of a C19-C32 segment

The C19-C32 segment 10 of swinholide A was prepared in 15 steps (8% yield, 82% ds) from (±)-16. Key steps include (i) the Sharpless epoxidation, 16 → 17, (ii) the acetal allylation, 15 → 23, (iii) the anti aldol addition, 13 + 14 → 1

Studies in macrolide synthesis: A stereocontrolled synthesis of oleandolide employing reagent- and substrate-controlled aldol reactions of (S)-1-(benzyloxy)-2-methylpentan-3-one

A highly stereocontrolled total synthesis of oleandolide (2), the aglycon of the macrolide antibiotic oleandomycin (1), has been completed in 8% overall yield (20 steps longest linear sequence, 26 steps in total) with 90% overall diastereoselectivity. Ini

ALDOL CONDENSATIONS OF CHIRAL ETHYLKETONES: CONTROL BY CHIRAL BORON REAGENTS.

The chiral reagents (+)- and (-)-(Ipc)2BOTf, in the presence of Et3N, are used to control the aldol condensation reactions of chiral ethylketone 5 with prochiral aldehydes.The SS isomer, 6 or 8, or SA isomer, 7 or 9, is then formed in >99 percentee and wi