116570-18-4

Upstream product

• 39274-99-2 tri-N-methyl-m-anisidinium; hydrochloride 
• 53290-32-7 m-MeOC₆H₄NMe₃(+)*I(-) 
• 99-07-0 3-Dimethylaminophenol 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Synthesis method of neostigmine bromide

The invention relates to the technical field of medicine synthesis, in particular to a synthesis method of neostigmine bromide. The synthesis method comprises the following steps of 1) selecting m-aminophenol of a formula (1) to react with halogenated methane to obtain halogenated quaternary ammonium salt methyl ether of a formula (2), 2) adding a catalyst into the halogenated quaternary ammonium salt methyl ether in the formula (2), and removing methyl ether to obtain m-phenolic hydroxyl quaternary ammonium salt in a formula (3), 3) forming a compound shown in a formula (4) from the m-phenolic hydroxyl quaternary ammonium salt shown in the formula (3) under a strong alkali condition, and 4) carrying out esterification reaction on the compound in the formula (4) and dimethyl carbamoyl bromide to obtain neostigmine bromide in a formula (5). According to the method, the m-aminophenol is adopted as the starting material, the price of the m-aminophenol is only one hundred of that of m-dimethylaminophenol, the cost of the neostigmine bromide can be greatly reduced when the m-aminophenol is used for synthesizing the neostigmine bromide, and mass production can be achieved.