116570-41-3

Basic information

• Product Name: 5,7-DIFLUORO ISATIN
• Synonyms: 5,7-DIFLUORO ISATIN;5,7-DIFLUOROINDOLINE-2,3-DIONE;UKRORGSYN-BB BBV-035724;5,7-Difluoro isatin 5,7-Difluoro indole-2,3-dione
• CAS NO: 116570-41-3
• Molecular Formula: C8H3F2NO2
• Molecular Weight: 183.11
• Mol File: 116570-41-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.578g/cm³
• Refractive Index: 1.558
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.07±0.20(Predicted)
• CAS DataBase Reference: 5,7-DIFLUORO ISATIN(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DIFLUORO ISATIN(116570-41-3)
• EPA Substance Registry System: 5,7-DIFLUORO ISATIN(116570-41-3)

Safety Data

• Hazardous Substances Data: 116570-41-3(Hazardous Substances Data)

Usage

General Description

5,7-Difluoro Isatin is a chemical compound with the molecular formula C8H3F2NO2. It belongs to the class of organic compounds known as isatins, which are characterized by a 2,3-dioxindole moiety. The two fluorine atoms at the 5th and 7th positions make 5,7-Difluoro Isatin a unique isatin derivative. 5,7-DIFLUORO ISATIN finds its applications in a wide range of synthetic chemistry reactions, largely due to its electronegative fluorine atoms that can modulate the reactivity of the molecule. It's often used as a building block in the synthesis of other complex chemical compounds and has potential applications in medicinal chemistry.

InChI:InChI=1/C8H3F2NO2/c9-3-1-4-6(5(10)2-3)11-8(13)7(4)12/h1-2H,(H,11,12,13)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 366-46-1 C₈H₆F₂N₂O₂ 

Relevant articles and documents

Design, synthesis and antiproliferative activity of novel benzothiazole derivatives conjugated with semicarbazone scaffold

Two series of novel benzothiazole derivatives conjugated with semicarbazone scaffold were designed and synthesized through a structure-based molecular hybridization strategy. All the target compounds were evaluated for their cytotoxicity in vitro against three cancer cell lines (HT-29, MKN-45 and H460) by standard MTT assay. The pharmacological results indicated that seven compounds (17h-n) exhibited comparable or even better antiproliferative activity in comparison with reference drugs Sorafenib and PAC-1. Particularly, compound 17i displayed remarkable cytotoxicity against tested three cancer cell lines with IC50 values of 0.84, 0.06 and 0.52 μM, which were 4.3-, 36.6-, 4.2-folds more potent than Sorafenib and 1.2-, 13.7-, 6.9-times more active than PAC-1, respectively.

Synthesis of insecticidal fluorinated anthranilic diamides

A series of highly active fluorinated anthranilic diamide insecticides have been prepared and their biological activity assessed on two aphid species in the search for systemically active compounds that control Hemiptera. In addition, we have demonstrated a new synthesis of N-aryl 3-fluoropyrazoles.