116572-09-9

Basic information

• Product Name: 1α-tert-Butyldimethylsilyloxy-6,7-dehydro-25,25-(ethylenedioxy)-27-norprevitamin D₃ tert-butyldimethylsilyl ether
• Synonyms: 1α-tert-Butyldimethylsilyloxy-6,7-dehydro-25,25-(ethylenedioxy)-27-norprevitamin D₃ tert-butyldimethylsilyl ether
• CAS NO: 116572-09-9
• Molecular Weight: 671.164
• Mol File: 116572-09-9.mol

Chemical Properties

• CAS DataBase Reference: 1α-tert-Butyldimethylsilyloxy-6,7-dehydro-25,25-(ethylenedioxy)-27-norprevitamin D₃ tert-butyldimethylsilyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 1α-tert-Butyldimethylsilyloxy-6,7-dehydro-25,25-(ethylenedioxy)-27-norprevitamin D₃ tert-butyldimethylsilyl ether(116572-09-9)
• EPA Substance Registry System: 1α-tert-Butyldimethylsilyloxy-6,7-dehydro-25,25-(ethylenedioxy)-27-norprevitamin D₃ tert-butyldimethylsilyl ether(116572-09-9)

Safety Data

• Hazardous Substances Data: 116572-09-9(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 116506-66-2 (3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-1-(2,2-dibromo-vinyl)-2-methyl-cyclohexene 
• 113393-82-1 Acetic acid (1S,5R)-5-acetoxy-3-(2,2-dibromo-vinyl)-2-methyl-cyclohex-2-enyl ester 
• 55448-87-8 (3S,5R)-3,5-Diacetoxy-2-methylcyclohex-1-ene-1-carboxaldehyde 
• 113375-47-6 (1R,2S,4R,6S)-2-Hydroxymethyl-1-methyl-4-(1-methylethenyl)-7-oxybicyclo<4.1.0>heptane 
• 4895-08-3 (1R,5R)-2-Methyl-5-(1-methylethenyl)-2-cyclohexen-1-methanol 
• 74064-30-5 (3S,5R)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-2-methylcyclohex-1-en-1-carboxaldehyde 
• 2244-16-8 (S)-p-mentha-6,8-dien-2-one 
• 116506-67-3 TB 
• 116535-66-1 De-A,B-25,25-(ethylenedioxy)-27-norcholest-8-en-8-yl trifluoromethanesulphonate 
• 100928-09-4 de-A,B-25,25-(ethylenedioxy)-27-norcholestan-8-one 
• 113375-50-1 (3S,5R)-5-Acetoxy-3-hydroxy-2-methylcyclohex-1-ene-1-carboxaldehyde 
• 113375-49-8 (1R,2S,4R,6S)-2-Hydroxymethyl-4-acetoxy-1-methyl-7-oxabicyclo<4.1.0>heptane 
• 75212-02-1 (3S,5R)-3,5-Dihydroxy-2-methyl-cyclohex-1-enecarbaldehyde 

Downstream Products

• 134328-87-3 1α-tert-Butyldimethylsilyloxy-25,25-(ethylenedioxy)-27-norvitamin D₃ tert-butyldimethylsilyl ether 
• 77531-53-4 1α-Hydroxy-25-oxo-27-norvitamin D₃ 
• 32222-06-3 calcitriol 
• 134328-86-2 1α-tert-Butyldimethylsilyloxy-25,25-(ethylenedioxy)-27-norprevitamin D₃ tert-butyldimethylsilyl ether 

Relevant articles and documents

Palladium-catalysed coupling of vinyl triflates with enynes and its application to the synthesis of 1α,25-dihydroxyvitamin D3

We describe a general approach, based on the palladium-catalysed coupling of enynes with vinyl triflates, for the construction of dienynes related to vitamin D metabolites and analogues. As an application of this method, an efficient convergent synthesis of 1α,25-dihydroxyvitamin D3 starting from the Inhoffen-Lythgoe diol (6a) and natural carvones has been carried out (11 steps, 28% overall yield from 6a). This strategy allows labelling of the side chain in the final steps of the synthesis.