116574-14-2

Basic information

• Product Name: 2-Cyanoacetic acid 1-(diphenylmethyl)-3-azetidinyl ester
• Synonyms: 2-CYANOACETIC ACID 1-(DIPHENYLMETHYL)-3-AZETIDINYL ESTER;Cyanoacetic acid 1-(diphenylmethyl)-3-azetidinyl ester;2-cyano-2-[1-(diphenylMethyl)azetidin-3-yl]acetic acid;1-Benzydryl-3-azetidinyl cyanoacetate;1-Benzhydrylazetidin-3-ylcyanoacetate;Acetic acid, 2-cyano-,1-(diphenylMethyl)-3-azetidinyl ester
• CAS NO: 116574-14-2
• Molecular Formula: C19H18N2O2
• Molecular Weight: 306.36
• EINECS: 1312995-182-4
• Mol File: 116574-14-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 446.43 °C at 760 mmHg
• Flash Point: 223.793 °C
• Appearance: /
• Density: 1.22
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Refrigerated.
• PKA: 1.83±0.10(Predicted)
• CAS DataBase Reference: 2-Cyanoacetic acid 1-(diphenylmethyl)-3-azetidinyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyanoacetic acid 1-(diphenylmethyl)-3-azetidinyl ester(116574-14-2)
• EPA Substance Registry System: 2-Cyanoacetic acid 1-(diphenylmethyl)-3-azetidinyl ester(116574-14-2)

Safety Data

• Hazardous Substances Data: 116574-14-2(Hazardous Substances Data)

Usage

General Description

2-Cyanoacetic acid 1-(diphenylmethyl)-3-azetidinyl ester is a complex organic compound. 2-Cyanoacetic acid 1-(diphenylmethyl)-3-azetidinyl ester is a type of ester, which are chemicals characterized by a carbon-oxygen double bond and single oxygen-carbon bond. It also includes a cyano group, signified by the presence of a nitrogen triple bonded to a carbon, and an azetidinyl group, which is a type of nitrogen-containing four-membered ring. The chemical also contains the diphenylmethyl group, which consists of two phenyl groups attached to a single carbon atom. The specific properties, uses, and safety measures would depend on its exact scientific and commercial context.

InChI:InChI=1/C19H18N2O2/c20-12-11-18(22)23-17-13-21(14-17)19(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17,19H,11,13-14H2

Upstream product

• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 372-09-8 cyanoacetic acid 
• 91-00-9 Benzhydrylamine 

Relevant articles and documents

Novel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-positions

Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N,N-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxyl ate, I-43 (CS-905), exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.