116574-74-4

Usage

Uses

3-Fluoropyrrolidine HCl

InChI:InChI=1/C4H8FN/c5-4-1-2-6-3-4/h4,6H,1-3H2

Upstream product

• 136725-52-5 (S)-N-CBz-3-fluoropyrrolidine 
• 163457-21-4 (R)-benzyl 3-fluoropyrrolidine-1-carboxylate 
• 479253-00-4 tert-butyl (S)-3-fluoropyrrolidine-1-carboxylate 

Downstream Products

• 1199814-73-7 (S)-4-bromo-N-(3-bromo-4-(2-(3-fluoropyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide 
• 1193752-33-8 C₁₇H₂₀FN₃O₄S 
• 1243675-22-0 C₃₇H₄₇ClF₃N₃O₂ 
• 1199814-74-8 C₁₉H₂₁Br₂FN₂O₂S 
• 1193752-32-7 C₁₇H₂₀FN₃O₄S 
• 1243675-21-9 C₃₇H₄₇ClF₃N₃O₂ 
• 1344033-96-0 (R)-6-((3-fluoropyrrolidin-1-yl)methyl)-2-(2-nitrophenyl)thiazolo[5,4-b]pyridine 
• 1446444-16-1 4-{[5-chloro-6-(3-fluoropyrrolidin-1-yl)pyridine-3-yl]oxy}-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide formate salt 

Relevant academic research and scientific papers

INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

CYCLOHEXYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors

Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good pharmacokinetic properties and was orally active in an oral glucose tolerance test in lean mice.