1165761-33-0

Basic information

• Product Name: dodecylcarbamic acid 2-(1,2,3-thiadiazol-4-yl)phenyl ester
• CAS NO: 1165761-33-0
• Molecular Weight: 389.562
• Mol File: 1165761-33-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dodecylcarbamic acid 2-(1,2,3-thiadiazol-4-yl)phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: dodecylcarbamic acid 2-(1,2,3-thiadiazol-4-yl)phenyl ester(1165761-33-0)
• EPA Substance Registry System: dodecylcarbamic acid 2-(1,2,3-thiadiazol-4-yl)phenyl ester(1165761-33-0)

Safety Data

• Hazardous Substances Data: 1165761-33-0(Hazardous Substances Data)

Upstream product

• 4202-38-4 dodecyl isocyanate 
• 59834-06-9 4-(2'-hydroxyphenyl)-1,2,3-thiadiazole 

Relevant articles and documents

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors

A series of para-substituted phenolic N-alkyl carbamates were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC50 values in the nM range, whereas inhibition of MGL required concentrations three orders of magnitude higher. The most potent compounds, dodecylcarbamic acid 4-(4,5-dihydrothiazol-2-yl)phenyl (12) and 4-(1,2,3-thiadiazol-4-yl)phenyl (26) esters, inhibited FAAH and MGL with IC50 values at the low-nanomolar (IC50s; 0.0063 and 0.012 μM) and the low-micromolar ranges (IC50s; 2.1 and 1.0 μM), respectively. Compound 26 also inhibited both FAAH-dependent AEA uptake and AEA hydrolysis (IC50; 0.082 μM) by intact RBL2H3 cells, and could also reduce 2-AG hydrolysis by these cells at concentrations ≥0.030 μM.