1165802-73-2Relevant academic research and scientific papers
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type I
Roche, Didier,Carniato, Denis,Leriche, Caroline,Lepifre, Franck,Christmann-Franck, Serge,Graedler, Ulrich,Charon, Christine,Bozec, Sophie,Doare, Liliane,Schmidlin, Fabien,Lecomte, Marc,Valeur, Eric
scheme or table, p. 2674 - 2678 (2009/12/31)
Benzylamides of pentanedioic acid were identified as inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by high-throughput screening. Optimisation to 2-adamantyl amides yielded inhibitors with single digit nanomolar IC50s on the 1
