1166-01-4

Basic information

• Product Name: 3' 4'-DICHLOROBENZAMIL
• Synonyms: 3' 4'-DICHLOROBENZAMIL;3,5-Diamino-6-chloro-N-[[(3,4-dichlorophenyl)methylamino](imino)methyl]-2-pyrazinecarboxamide;Dichlorobenzamil;N-[Imino[(3,4-dichlorophenylmethyl)amino]methyl]-3,5-diamino-6-chloro-2-pyrazinecarboxamide;3,5-bis(azanyl)-6-chloro-N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]pyrazine-2-carboxamide;3,5-diamino-6-chloro-N-[N'-(3,4-dichlorobenzyl)carbamimidoyl]pyrazinamide;3,5-diamino-6-chloro-N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]pyrazine-2-carboxamide
• CAS NO: 1166-01-4
• Molecular Formula: C₁₃H₁₂Cl₃N₇O
• Molecular Weight: 425.1
• Mol File: 1166-01-4.mol

Chemical Properties

• Appearance: yellow/solid
• Density: 1.77 g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO: 30 mg/mL, soluble
• CAS DataBase Reference: 3' 4'-DICHLOROBENZAMIL(CAS DataBase Reference)
• NIST Chemistry Reference: 3' 4'-DICHLOROBENZAMIL(1166-01-4)
• EPA Substance Registry System: 3' 4'-DICHLOROBENZAMIL(1166-01-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1166-01-4(Hazardous Substances Data)

Usage

Uses

Used in Biological Research:
3'4'-Dichlorobenzamil is used as a potent inhibitor for the Na+/Ca2+ exchanger, which is essential for regulating calcium levels in cells. This application is crucial in understanding the role of calcium homeostasis in various cellular processes.
Used in Chemical Research:
3'4'-Dichlorobenzamil is used as a selective inhibitor to study the effects of blocking the Na+/Ca2+ exchanger on different physiological functions. This helps researchers to investigate the underlying mechanisms of various conditions related to calcium homeostasis.
Used in Cellular Mechanisms Studies:
3'4'-Dichlorobenzamil is used as a research tool in examining cellular mechanisms of heart disease, brain disorders, and other conditions related to calcium homeostasis. Its ability to block the Na+/Ca2+ exchanger provides insights into the role of calcium regulation in these diseases.
Used in Drug Development:
Although 3'4'-Dichlorobenzamil has potential toxicities in high concentrations, it is safe to handle under standard lab conditions. This makes it a valuable compound for drug development, as it can be used to study the effects of inhibiting the Na+/Ca2+ exchanger on various physiological functions and potentially lead to the discovery of new therapeutic agents.