116622-94-7

Basic information

• Product Name: 2-(2-fluorophenyl)acetohydrazide
• Synonyms: 2-(2-fluorophenyl)acetohydrazide
• CAS NO: 116622-94-7
• Molecular Formula: C₈H₉FN₂O
• Molecular Weight: 168.1682632
• Mol File: 116622-94-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-(2-fluorophenyl)acetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorophenyl)acetohydrazide(116622-94-7)
• EPA Substance Registry System: 2-(2-fluorophenyl)acetohydrazide(116622-94-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 116622-94-7(Hazardous Substances Data)

Usage

Structure

A hydrazide derivative of 2-(2-fluorophenyl)acetic acid

Classification

Member of the acetohydrazide family

Medicinal properties

Potential ability to inhibit the activity of certain enzymes

Applications

Possible use in pharmaceutical research and drug development (requires further research)

Safety considerations

May have specific handling requirements and safety concerns

Upstream product

• 57486-67-6 methyl o-fluorophenylacetate 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 451-81-0 2-(2-fluorophenyl)acetyl chloride 

Downstream Products

• 554436-95-2 4-amino-3-(2-fluorobenzyl)-1H-1,2,4-triazole-5(4H)-thione 
• 1427501-02-7 3-(2-fluorobenzyl)-6-(furan-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 36209-49-1 4-amino-5-(4-methoxyphenyl)-2,3-dihydro-4H-1,2,4-triazole-3-thione 
• 923550-56-5 3-(2-fluorobenzyl)-6-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 849913-13-9 3-(4-methoxyphenyl)-6-(pyridin-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 537017-29-1 3-(4-methoxyphenyl)-6-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 577700-42-6 3-(4-methoxyphenyl)-6-(thiophen-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 
• 578754-51-5 3-(4-ethoxyphenyl)-6-(thiophen-2-ylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 

Relevant articles and documents

TRICYCLIC COMPOUNDS AND THEIR USE

Tricyclic compounds and their use are provided. More specifically, tricyclic compounds, pharmaceutical compositions containing them, methods for preparing them, and their use in therapy are also provided.

Synthesis and Biological Evaluation of New (-)-Gossypol-Derived Schiff Bases and Hydrazones

A series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. However, in an antibacterial test, compounds 8a and 8b inhibited Staphylococcus aureus and Bacillus cereus and compound 8e inhibited only Staphylococcus aureus at the same MIC values of 1024 μg/ml.

Acetylcholinesterase inhibition activity of some quinolinyl substituted triazolothiadiazole derivatives

A series of aralkanoic acids was converted into aralkanoic acid hydrazides through their esters formation. The aralkanoic acid hydrazides upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazinate salts, which on refluxing with aqueous hydrazine hydrate yielded 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles. The target compounds, 3-aralkyl-6-(substitutedquinolinyl) [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, were synthesized by condensing various quinolinyl substituted carboxylic acids with 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles in phosphorus oxychloride. The structures of the newly synthesized triazolothiadiazoles were characterized by IR, 1H NMR, 13C NMR, and elemental analysis studies. The structure of one of the 5-aralkyl-4-amino-3-mercapto-1,2,4-triazoles was unambiguously deduced by single crystal X-ray diffraction analysis. All the synthesized compounds were screened for their acetylcholinesterase inhibition activities. Four of the triazolothiadiazoles exhibited excellent acetylcholinesterase inhibition activities as compared to the reference inhibitor.