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1166227-58-2

(S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[2-(2-fluoro-phenyl)-4'-methyl-[4,5']bithiazolyl-2'-yl]-amide} is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1166227-58-2 Structure

  • Basic information

    1. Product Name: (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[2-(2-fluoro-phenyl)-4'-methyl-[4,5']bithiazolyl-2'-yl]-amide}
    2. Synonyms:
    3. CAS NO:1166227-58-2
    4. Molecular Formula:
    5. Molecular Weight: 431.515
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1166227-58-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[2-(2-fluoro-phenyl)-4'-methyl-[4,5']bithiazolyl-2'-yl]-amide}(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[2-(2-fluoro-phenyl)-4'-methyl-[4,5']bithiazolyl-2'-yl]-amide}(1166227-58-2)
    11. EPA Substance Registry System: (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-{[2-(2-fluoro-phenyl)-4'-methyl-[4,5']bithiazolyl-2'-yl]-amide}(1166227-58-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1166227-58-2(Hazardous Substances Data)

1166227-58-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1166227-58-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,6,2,2 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1166227-58:
(9*1)+(8*1)+(7*6)+(6*6)+(5*2)+(4*2)+(3*7)+(2*5)+(1*8)=152
152 % 10 = 2
So 1166227-58-2 is a valid CAS Registry Number.

1166227-58-2Downstream Products

1166227-58-2Relevant articles and documents

Identification and optimisation of a 4′,5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors

Fairhurst, Robin A.,Imbach-Weese, Patricia,Gerspacher, Marc,Caravatti, Giorgio,Furet, Pascal,Zoller, Thomas,Fritsch, Christine,Haasen, Dorothea,Trappe, Joerg,Guthy, Daniel A.,Arz, Dorothee,Wirth, Jasmin

, p. 3569 - 3574 (2015)

Abstract Exploring the affinity-pocket binding moiety of a 2-aminothiazole (S)-proline-amide-urea series of selective PI3Kα inhibitors using a parallel-synthesis approach led to the identification of a novel 4′,5-bisthiazole sub-series. The synthesis and optimisation of both the affinity pocket and (S)-proline amide moieties within this 4′,5-bisthiazole sub-series are described. From this work a number of analogues, including 14 (A66) and 24, were identified as potent and selective PI3Kα inhibitor in vitro tool compounds.

ORGANIC COMPOUNDS

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Page/Page column 63, (2009/07/25)

The resent invention relates to a com ound of formula (I) and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-

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