1166228-20-1 Usage
Description
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)thio]-2-hydroxy-2-methyl-propanamide is a chemical compound with a complex structure, characterized by its cyano, trifluoromethyl, and fluorophenyl groups. It is an important intermediate in the synthesis of pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)thio]-2-hydroxy-2-methyl-propanamide is used as an intermediate in the synthesis of Bicalutamide (B382000) related compound for the treatment of prostate cancer. Its unique structure allows for the development of potent and selective antiandrogens, which play a crucial role in managing the progression of prostate cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1166228-20-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,6,2,2 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1166228-20:
(9*1)+(8*1)+(7*6)+(6*6)+(5*2)+(4*2)+(3*8)+(2*2)+(1*0)=141
141 % 10 = 1
So 1166228-20-1 is a valid CAS Registry Number.
1166228-20-1Relevant articles and documents
Synthesis of potential impurities of bicalutamide
Bhise, Nandu Baban,Sathe, Dhananjay Govind,Radhakrishanan, Tarur,Deore, Raviraj
experimental part, p. 1516 - 1526 (2009/10/17)
Bicalutamide is an oral nonsteroidal, anti-androgen drug used for prostate cancer. It binds to the androgen receptor. During the bulk synthesis of bicalutamide, various impurities are formed. The present work details the development of simple processes for the preparation of impurities of bicalutamide, viz bical-sulfoxides (6), bical-deshydroxy (10), bical-desfluoro (10a), bical-2-fluoro (10b), and bical-3-fluoro (10c). Copyright Taylor & Francis Group, LLC.
