116632-24-7

Basic information

• Product Name: 2-Amino-4,6-dichloropyridine
• Synonyms: 4,6-DICHLORO-PYRIDIN-2-YLAMINE;2-AMINO-4,6-DICHLOROPYRIDINE;4,6-Dichloro-2-aminopyridine;2-AMINO-4,6-DICHLOROPYRIDINE, 98+%;4,6-Dichloropyridin-2-amine;4,6-Dichloro-pyridine-2-ylamine;2-Amino-4,6-dischloropyridine;2-Pyridinamine, 4,6-dichloro-
• CAS NO: 116632-24-7
• Molecular Formula: C₅H₄Cl₂N₂
• Molecular Weight: 163
• Product Categories: Amines;Pyridines;Heterocycle-Pyridine series
• Mol File: 116632-24-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 112.5 °C
• Boiling Point: 287.9 °C at 760 mmHg
• Flash Point: 127.9 °C
• Appearance: /
• Density: 1.497 g/cm³
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.76±0.35(Predicted)
• CAS DataBase Reference: 2-Amino-4,6-dichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4,6-dichloropyridine(116632-24-7)
• EPA Substance Registry System: 2-Amino-4,6-dichloropyridine(116632-24-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 116632-24-7(Hazardous Substances Data)

Usage

Uses

2-Amino-4,6-Dichloropyridine is a useful research chemical.

InChI:InChI=1/C5H4Cl2N2/c6-3-1-4(7)9-5(8)2-3/h1-2H,(H2,8,9)

Upstream product

• 1017789-38-6 tert-butyl (4,6-dichloropyridin-2-yl)carbamate 
• 16063-69-7 2,4,6-trichloropyridine 

Downstream Products

• 1214242-09-7 6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 
• 1452573-02-2 4-chloro-6-(2-phenylethynyl)pyridin-2-amine 
• 1075215-57-4 N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine 

Relevant articles and documents

High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences

A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected substrates within minutes using acetonitrile as the solvent and without the use of acidic conditions or additional workups. Highly efficient, multistep reaction sequences in flow are also demonstrated wherein no extraction or isolation was required between steps.

9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.