116668-80-5

Basic information

• Product Name: METHYL 3'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLATE
• Synonyms: RARECHEM AL BF 1353;AKOS BAR-1134;METHYL 3'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLATE
• CAS NO: 116668-80-5
• Molecular Formula: C15H14O2
• Molecular Weight: 226.27
• Mol File: 116668-80-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 354.4±21.0 °C(Predicted)
• Appearance: /
• Density: 1.083±0.06 g/cm3(Predicted)
• CAS DataBase Reference: METHYL 3'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLATE(116668-80-5)
• EPA Substance Registry System: METHYL 3'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLATE(116668-80-5)

Safety Data

• Hazardous Substances Data: 116668-80-5(Hazardous Substances Data)

Upstream product

• 610-94-6 2-bromobenzoic acid methyl ester 
• 17933-03-8 m-tolylboronic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 591-17-3 meta-bromotoluene 

Downstream Products

• 107412-71-5 3'-methyl-[1,1'-biphenyl]-2-carboxylic acid 

Relevant articles and documents

Nickel(0)/imidazolium carbene catalyst system for efficient cross-coupling of aryl bromides and chlorides with organomanganese reagents

N,N′-Bis(2,6-diisopropylphenyl)imidazolium chloride associated with nickel(II) acetylacetonate (3-5 mol%) was used as catalyst to efficiently cross-couple functionalized aryl bromides with organomanganese reagents. The reactions were performed between 0°C and room temperature, giving unsymmetrical biaryls in 0.25 to 24 h with 52 to 100% yields for isolated materials. Aryl chlorides showed slightly diminished reactivity in Ni/2 IPr-catalyzed cross-couplings and good yields could only be attained with activated or neutral substrates.

Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite

A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.

Silver-Catalyzed C(sp2)-H Functionalization/C-O Cyclization Reaction at Room Temperature

Silver-catalyzed C(sp2)-H functionalization/C-O cyclization has been developed. The scalable reaction proceeds at room temperature in an open flask. The present method exhibits good functional-group compatibility because of the mild reaction conditions. Using a AgNO3 catalyst and a (NH4)2S2O8 oxidant in CH2Cl2/H2O solvent, various lactones are obtained in good to excellent yields. A kinetic isotope effect (KIE) study indicates that the reaction may occur via a radical process.