116672-29-8Relevant academic research and scientific papers
Anticonvulsant Activity of Phenylmethylenehydantoins: A Structure-Activity Relationship Study
Thenmozhiyal, Jeyanthi Chinnappa,Wong, Peter Tsun-Hon,Chui, Wai-Keung
, p. 1527 - 1535 (2004)
Phenylmethylenehydantoins (PMHs) and their des-phenyl analogues were synthesized and evaluated for anticonvulsant activity using the maximal electroshock seizure (MES) assay. The phenyl rings of PMHs were substituted with a wide spectrum of groups, and th
Evaluation of michael-type acceptor reactivity of 5-benzylidenebarbiturates, 5-benzylidenerhodanines, and related heterocycles using NMR
Arsovska, Emilija,Trontelj, Jurij,Zidar, Nace,Tomai, Tihomir,Mai, Lucija Peterlin,Kikelj, Danijel,Plavec, Janez,Zega, Anamarija
, p. 637 - 644 (2014/12/11)
Despite existing experimental and computational tools to assess the risk, the non-specific chemical modification of protein thiol groups remains a significant source of false-positive hits, particularly in academic drug discovery. Herein, we describe the
Hydantoin derivatives
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, (2008/06/13)
The invention relates to compounds of the formula I STR1 in which R1, R2, R3, R4 and Y have the meanings indicated in Claim 1, to processes for their preparation and their use as active pharmacological substance
Thermal Equilibration of Z- and E-Isomers of 5-Arylmetylenehydantoins. Evidence for Non-bonded Aromatic ?...Methyl Attractions
Tan, Sau-Fun,Ang, Kok-Peng,How, Gee-Fung
, p. 2045 - 2050 (2007/10/02)
Standard free energy differences between the Z- and E-isomers of 14 5-arylmethylenehydantoins have been estimated by thermal equilibration in dimethyl sulphoxide.The Z-configuration is more stable for the N-substituted compounds while the E-configuration is preferred for those N-1 methyl derivatives with only para-substituents in the aryl group.The ΔG0 values vary with the nature of the para substituents.For those N-1 methyl derivatives with two ortho-substituents in the aryl group, the configurational preference is dependent on the electronic effects of these aryl subtituents, suggesting the presence of non-bonded aromatic ?...Me interactions.The factors influencing the relative stabilities of Z- and E-isomers are discussed.
