1166756-72-4

Basic information

• Product Name: 3-Bromo-5-chloro-2-methylaniline
• Synonyms: 3-Bromo-5-chloro-2-methylaniline;3-Bromo-5-chloro-2-methylbenzenamine
• CAS NO: 1166756-72-4
• Molecular Formula: C₇H₇BrClN
• Molecular Weight: 220.49418
• Mol File: 1166756-72-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 297.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.619±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-5-chloro-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-chloro-2-methylaniline(1166756-72-4)
• EPA Substance Registry System: 3-Bromo-5-chloro-2-methylaniline(1166756-72-4)

Safety Data

• Hazardous Substances Data: 1166756-72-4(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-chloro-2-methylaniline, also known as 5-Chloro-3-bromo-2-methylaniline, is a chemical compound with the molecular formula C7H7BrClN. It is a derivative of aniline and is commonly used in the synthesis of various pharmaceuticals and organic compounds. 3-Bromo-5-chloro-2-methylaniline is a solid at room temperature and is insoluble in water but soluble in organic solvents. It is a potentially hazardous chemical and should be handled with care as it may cause skin and eye irritation upon contact. Additionally, it may be harmful if inhaled or ingested and should be stored and handled in a well-ventilated area with proper safety precautions.

Upstream product

• 219312-44-4 5-chloro-2-methyl-3-nitro-aniline 
• 885518-95-6 1-bromo-5-chloro-2-methyl-3-nitrobenzene 

Relevant articles and documents

Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a multifactorial autoimmune disease, representing a major clinical challenge. Herein, a strategy of dual-targeting approach employing retinoic acid receptor-related orphan receptor γ-t (RORγt) and dihydroorotate dehydrogenase (DHODH) was proposed for the treatment of IBD. Dual RORγt/DHODH inhibitors are expected not only to reduce RORγt-driven Th17 cell differentiation but also to mitigate the expansion and activation of T cells, which may enhance anti-inflammatory effects. Starting from 2-aminobenzothiazole hit 1, a series of 2-aminotetrahydrobenzothiazoles were discovered as potent dual RORγt/DHODH inhibitors. Compound 14d stands out with IC50 values of 0.110 μM for RORγt and of 0.297 μM for DHODH. With acceptable mouse pharmacokinetic profiles, 14d exhibited remarkable in vivo anti-inflammatory activity and dose-dependently alleviated the severity of dextran sulfate sodium (DSS)-induced acute colitis in mice. Taken together, the present study provides a novel framework for the development of therapeutic agents for the treatment of IBD.