1166835-61-5Relevant articles and documents
Improved peptide prodrugs of 5-ALA for PDT: Rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization
Giuntini, Francesca,Bourré, Ludovic,MacRobert, Alexander J.,Wilson, Michael,Eggleston, Ian M.
supporting information; experimental part, p. 4026 - 4037 (2010/01/06)
Twenty-seven dipeptide derivatives of general structure Ac-Xaa-ALA-OR were synthesized as potential prodrugs for 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). Xaa is an R-amino acid, chosen to provide a prodrug with appropriately tailored l