116699-66-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 90778-56-6 2-(1-Bromo-ethyl)-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol 
• 90778-56-6 N-(p-tolylsulfonyl)-2(S)-<1'(R)-bromoethyl>-3(R)-hydroxypyrrolidine 
• 90778-56-6 (2S,3S)-2-((S)-1-Bromo-ethyl)-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol 
• 90778-73-7 2-(1-Iodo-ethyl)-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol 
• 90778-73-7 N-(p-tolylsulfonyl)-2(S)-<1'(R)-iodoethyl>-3(R)-hydroxypyrrolidine 
• 90778-73-7 (2S,3S)-2-((S)-1-Iodo-ethyl)-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol 

Relevant academic research and scientific papers

Catalyst- and Reagent-Free Formal Aza-Wacker Cyclizations Enabled by Continuous-Flow Electrochemistry

The development of efficient and sustainable methods to access saturated N-heterocycles is of great importance because of the prevalence of these structures in natural products and bioactive compounds. Pd-catalyzed aza-Wacker type cyclization is a powerful method and provides access to N-heterocycles bearing an alkene moiety available for further synthetic manipulations from readily available materials. Herein we disclose a catalyst- and reagent-free formal aza-Wacker type cyclization reaction for the synthesis of functionalized saturated N-heterocycles. Key to the success is to conduct the reactions in a continuous-flow electrochemical reactor without adding supporting electrolyte or additives. The reactions are characterized by broad tolerance of di-, tri- and tetrasubstituted alkenes.