116724-02-8

Basic information

• Product Name: (R)-(1-bromopropan-2-yl)benzene
• Synonyms: (R)-(1-bromopropan-2-yl)benzene
• CAS NO: 116724-02-8
• Molecular Weight: 199.09
• Mol File: 116724-02-8.mol

Chemical Properties

• CAS DataBase Reference: (R)-(1-bromopropan-2-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(1-bromopropan-2-yl)benzene(116724-02-8)
• EPA Substance Registry System: (R)-(1-bromopropan-2-yl)benzene(116724-02-8)

Safety Data

• Hazardous Substances Data: 116724-02-8(Hazardous Substances Data)

Upstream product

• 7782-26-5 (R)-2-Phenylpropionic acid 
• 214492-00-9 (4R)-4-benzyl-3-[(2R)-2-phenylpropionyl]oxazolidin-2-one 
• 144838-82-4 (4R)-4-Benzyl-3-(2-phenylacetyl)-1,3-oxazolan-2-one 
• 103-82-2 phenylacetic acid 
• 1123-85-9 (RS)-2-phenyl-1-propanol 
• 1123-85-9 (+)-(R)-2-phenylpropanol 

Downstream Products

• 471241-33-5 diethyl 2-[(S)-2-phenylpropyl]-2-ethylmalonate 
• 54646-14-9 (S)-3-phenylbutan-1-amine 
• 211230-12-5 (S)-3-phenylbutyronitrile 
• 2406-19-1 methyl (S)-(+)-4-phenylpentanoate 
• 848413-14-9 (2RS,4S)-2-methyl-4-phenylpentanoic acid 
• 848413-16-1 (2RS,4S)-2-methyl-4-phenylpentan-1-ol 

Relevant articles and documents

Potent Kv1.3 inhibitors from correolide - Modification of the C18 position

Correolide (1) was converted to a new series of tetracyclic Kv1.3 blockers 2. SAR for this class of compounds in two functional assays, Rb_Kv and human T cell proliferation, is presented herein. Kv1.3, the voltage-gated potassium channel in human T cells, represents a new target for treating immunosuppression and autoimmune diseases. Correolide (1), a pentacyclic natural product, is a potent and selective Kv1.3 channel blocker. Simplification of correolide via removal of its E-ring generates enone 4, whose modification produced a new series of tetracyclic Kv1.3 blockers. The structure-activity relationship for this class of compounds in two functional assays, Rb_Kv and human T cell proliferation, is presented herein. The most potent analog 43 is 15-fold more potent than correolide as inhibitor of human T cell proliferation.

Diastereoselective noncovalent synthesis of hydrogen-bonded double-rosette assemblies

Chiral centers present either in the dimelamine components of calix[4]arene 1 or in the cyanurate components CA quantitatively induce one handedness (P or M) in the corresponding hydrogen-bonded assemblies 13·(CA)6 (de>98%). The high degree of chiral induction results from the presence of six chiral centers in close proximity (Cα) to the core of the assembly. A much lower level of chiral induction is observed for assemblies with chiral centers that are more remote (Cβ). All diastereomerically pure assemblies 13·(CA)6 exhibit very high CD activities (|Δεmax|～100 L mol-1cm-1), in sharp contrast to the low CD activities (|Δεmax|≤8 L mol-1cm-1) shown by the free components. The assemblies display spontaneous resolution under thermo-dynamically controlled conditions (i.e., heteromeric assemblies containing both peripheral R and S centers are not observed. Remarkable assembly behavior is observed if both components 1 and CA are chiral. In general, formation of well-defined assemblies is only observed when both components contain unidirectional information for the induction of either M or P chirality.

Tetracyclic triterpene derivatives with immunosuppressant activity

The compounds of Formula I are useful as immunosuppressive agents.

Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity

The compounds of Formula I are useful as immunosuppressive agents.