116726-01-3Relevant academic research and scientific papers
Topsentin, Bromotopsentin, and Dihydrodeoxybromotopsentin: Antiviral and Antitumor Bis(indolyl)imidazoles from Caribbean Deep-Sea Sponges of the Family Halichondriidae Structural and Synthetic Studies
Tsujii, Shinji,Rinehart, Kenneth L.,Gunasekera, Sarath P.,Kashman, Yoel,Cross, Susan S.,et al.
, p. 5446 - 5453 (2007/10/02)
Isolation and structure elucidation of topsentin (1) and bromotopsentin (2) are described.These novel indole alkaloids have been shown to have antitumor and antiviral activities.Their structures were determined on the basis of spectral data, and bromotopsentin was correlated structurally with topsentin by catalytic debromination.Syntheses of 1 and several analogues are also reported.
