116748-66-4

Usage

Uses

Used in Pharmaceutical Industry:
4'-Fluoro[1,1'-biphenyl]-4-sulfonyl chloride is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of biologically active molecules. Its reactivity allows for the creation of a diverse range of compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4'-Fluoro[1,1'-biphenyl]-4-sulfonyl chloride serves as a valuable precursor in the production of agrochemicals, aiding in the development of effective and targeted pest control solutions.
Used in Dye Synthesis:
4'-Fluoro[1,1'-biphenyl]-4-sulfonyl chloride is utilized as a reactive intermediate in the synthesis of dyes, contributing to the creation of a variety of colorants for different applications, including textiles and printing inks.
Used in Advanced Materials:
4'-FLUORO[1,1'-BIPHENYL]-4-SULFONYL CHLORIDE is also used as a building block in the development of advanced materials, such as high-performance polymers and specialty chemicals, due to its unique structural and reactive properties.

Upstream product

• 777056-02-7 4'-fluorobiphenyl-4-sulfonic acid 
• 324-74-3 4-fluoro-biphenyl 

Downstream Products

• 116748-58-4 4'-Fluoro-biphenyl-4-sulfonic acid 2-formyl-phenyl ester 
• 220441-09-8 1-(4'-fluorobiphenyl-4-sulfonylamino) cyclopentanecarboxylic acid benzyl ester 
• 1158989-68-4 1,1-dimethylethyl (2S)-4-[(4-{[(4'-fluoro-4-biphenylyl)sulfonyl]amino}phenyl)methyl]-2-methyl-1-piperazinecarboxylate 
• 1158989-67-3 1,1-dimethylethyl (2S)-4-({4-[[(4'-fIuoro-4-biphenylyl)sulfonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate 
• 1456602-11-1 5-(2-(4'-fluoro-N-methylbiphenyl-4-ylsulfonamido)-N-(4-heptylbenzyl)acetamido)-2-hydroxybenzoic acid 
• 1456601-89-0 methyl 5-(2-(4'-fluoro-N-methylbiphenyl-4-ylsulfonamido)-N-(4-heptylbenzyl)acetamido)-2-hydroxybenzoate 
• 116748-25-5 C₆₄H₅₈F₂N₄O₆S₂ 
• 253194-89-7 (S)-4-(4'-Fluoro-biphenyl-4-sulfonyl)-2,2-dimethyl-[1,4]thiazepane-3-carboxylic acid 

Relevant academic research and scientific papers

Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13

The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would therefore be a novel disease modifying therapy for the treatment of arthritis. Our efforts have resulted in the discovery of a series of carboxylic acid inhibitors of MMP-13 that do not significantly inhibit the related MMP-1 (collagenase-1) or tumor necrosis factor-α (TNF-α) converting enzyme (TACE). It has previously been suggested (but not proven) that inhibition of the latter two enzymes could lead to side effects. A promising carboxylic acid lead 9 was identified and a convergent synthesis developed. This paper describes the optimization of 9 and the identification of a compound 24f for further development. Compound 24f is a subnanomolar inhibitor of MMP-13 (IC50 value 0.5 nM and Ki of 0.19 nM) having no activity against MMP-1 or TACE (IC50 of >10000 nM). Furthermore, in a rat model of MMP-13-induced cartilage degradation, 24f significantly reduced proteoglycan release following oral dosing at 30 mg/kg (75% inhibition, p 0.05) and at 10 mg/kg (40% inhibition, p 0.05).

Development and characterization of biphenylsulfonamides as novel inhibitors of bone resorption

Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used treatments for these diseases. We have identified and characterized a series of novel biphenylsulfona

ARYL ALKYL SULFONAMIDES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS

The present invention pertains to certain aryl alkyl sulfonamides and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formula: [Inser