116754-55-3Relevant academic research and scientific papers
Visible-light-induced chemoselective deboronative alkynylation under biomolecule-compatible conditions
Huang, Hanchu,Zhang, Guojin,Gong, Li,Zhang, Shuaiyan,Chen, Yiyun
, p. 2280 - 2283 (2014/03/21)
Here, we report a visible-light-induced deboronative alkynylation reaction, which is redox-neutral and works with primary, secondary and tertiary alkyl trifluoroborates or boronic acids to generate aryl, alkyl and silyl substituted alkynes. This reaction is highly chemoselective and performs well on substrates containing alkenes, alkynes, aldehydes, ketones, esters, nitriles, azides, aryl halides, alkyl halides, alcohols, and indoles, with no detectable occurrence of side reactions. The mechanism of this novel C(sp3)-C(sp) bond coupling reaction was investigated by luminescence quenching, radical trapping, on-off light, and 13C-isotopic-labeling experiments. This reaction can be performed in neutral aqueous conditions, and it is compatible with amino acids, nucleosides, oligosaccharides, nucleic acids, proteins, and cell lysates.
Methode de synthese d'acides gras marques substitues ou non en α et en β
Apparu, Marcel,Comet, Michel,Leo, Pierre M.,Mathieu, Jean-Paul,Du Moulinet, Amaury,et al.
, p. 118 - 124 (2007/10/02)
2-Propyn-1-ol and the dibromides Br(CH2)nBr (n = 10-12) have been used as starting materials for the synthesis of α- and β-methyl-branched fatty acids (C16) labeled with 123I at the ω-position.The methyl groups are introduced through the use of the lithium salt of either propanoic or isobutyric acid.The synthesis of *IC6H5(CH2)14COOH and *IC6H5(CH2)12CH(CH3)CH2COOH have been achieved in the same way starting from phenylacetylene.In each case, the radioactive iodine atom is introduced by an I/*I exchange reaction.
