116763-11-2Relevant articles and documents
Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies
Casimiro-Garcia, Agustin,Bigge, Christopher F.,Davis, Jo Ann,Padalino, Teresa,Pulaski, James,Ohren, Jeffrey F.,McConnell, Patrick,Kane, Christopher D.,Royer, Lori J.,Stevens, Kimberly A.,Auerbach, Bruce J.,Collard, Wendy T.,McGregor, Christine,Fakhoury, Stephen A.,Schaum, Robert P.,Zhou, Hairong
, p. 4883 - 4907 (2008/12/21)
A new series of α-aryl or α-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the commonly used ether moiety that joins the central phenyl ring with
Peptide Synthesis Using the Pyrrole Ring as an Amino Protecting Group
Kashima, Choji,Maruyama, Tatsuya,Harada, Kazuo,Hibi, Shigeki,Omote, Yoshimori
, p. 601 - 645 (2007/10/02)
The utility of a pyrrole ring as an amino protecting group for amino acids in peptide synthesis has been studied.The N-termini of various amino acids (1) were protected with a pyrrole ring by treatment with 2,5-dimethoxytetrahydrofuran (10) to give 2-substituted 2-(1-pyrrolyl)acetic acids (11).The peptide bond between (11) and amino acid methyl ester (2) was formed using N,N'-dicyclohexylcarbodiimide, and the pyrrole ring was cleaved by ozonolysis and hydrolysis without the cleavage of a peptide bond to give the corresponding dipeptide compounds (26) in good yields.
