1167995-48-3Relevant academic research and scientific papers
Click chemistry inspired synthesis of novel ferrocenyl-substituted amino acids or peptides
Sudhir, V. Sai,Venkateswarlu,Musthafa, O. T. Muhammed,Sampath,Chandrasekaran, Srinivasan
, p. 2120 - 2129 (2009)
This work reports on the synthesis of a wide range of ferro- cenyl-substituted amino acids and peptides in excellent yield. Conjugation is established via copper-catalyzed 1,3- dipolar cycloaddition. Two complementary strategies were employed for conjugation, one involving cycloaddition of amino acid derived azides with ethynyl ferrocene 1 and the other involves cycloaddition between amino acid derived al- kynes with ferrocene-derived azides 2 and 3. Labeling of amino acids at multiple sites with ferrocene is discussed. A new route to 1,1'-unsymmetrically substituted ferrocene conjugates is reported. A novel ferrocenophane 19 is accessed via bimolecular condensation of amino acid derived bis- alkyne 9b with the azide 2. The electrochemical behavior of some selected ferrocene conjugates has been studied by cyclic voltammetry.
