116805-89-1

Upstream product

• 71-43-2 benzene 
• 720712-06-1 1-(2-tert-butylphenyl)-3,4-dihydro-1H-pyridin-2-one 
• 49828-17-3 1,6-diphenyl-3,4-dihydro-1H-pyridin-2-one 
• 1335136-23-6 C₁₇H₁₇NO 
• 720712-03-8 4-(2-tert-butyl-phenylcarbamoyl)-butyric acid 
• 720712-05-0 1-(2-tert-butylphenyl)-6-hydroxypiperidin-2-one 
• 720712-04-9 1-(2-tert-butylphenyl)-piperidine-2,6-dione 
• 98-80-6 phenylboronic acid 
• 5768-13-8 N-phenylglutarimide 
• 1121-89-7 piperidine-2,6-dione 
• 1027716-74-0 phosphoric acid 6-oxo-1-phenyl-1,4,5,6-tetrahydro-pyridin-2-yl ester diphenyl ester 

Downstream Products

• 108979-48-2 1,6-diphenyl-5,6-dihydro-1H-pyridin-2-one 
• 1027035-96-6 3-benzenesulfinyl-1,6-diphenyl-piperidin-2-one 

Relevant academic research and scientific papers

Electrophilic intramolecular cyclization of functional dervatives of unsaturated compounds: VII. Synthesis of 5-arylsulfanyl-6-phenylpiperidin-2-ones in the absence of salt additives and their selective reduction and oxidation

Cinnamylacetamides reacted with arylsulfenyl chlorides in chloroform in the absence of LiClO4 affording 5-(arylsulfanyl)-6-phenylpiperidin-2-ones. Their reduction with a system LiAlH4-AlCl3 resulted in 3-(tolylsulfanyl)-1,

Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates

A concise and short synthetic entry to 5,6-dihydropyridin-2-one derivatives has been developed by means of palladium(0)-catalyzed cross-coupling of cyclic ketene aminal phosphates.

Stereoselectivity in reactions of atropisomeric lactams and imides

A range of reactions of cyclic lactam systems is described in which an atropisomeric C-N axis controls the stereochemical outcome of ring substitution or addition. In the case of enantiopure menthol adducts, substitution via N-acyliminium intermediates occurred with essentially complete control. However, the range of nucleophiles that participate in the reaction is very limited and at present the removal of the N-aryl substituent is problematic. A six-membered enamide is of moderate configurational stability and the axis exerts synthetically useful levels of control over enolate alkylations of the system. A novel Lewis acid mediated enamide arylation process was identified.

Lactam derivatives

There is disclosed a lactam derivative of the formula: STR1 wherein R1 is a substituted or unsubstituted phenyl group; R2 is a substituted or unsubstituted phenyl group, a cycloalkyl group or a nitrogen-containing 6-membered heterocy