116818-74-7

Usage

Class

Piperazine organic compounds

Use

Production of pharmaceutical drugs

Specific application

Intermediate in the synthesis of Quetiapine fumarate (antipsychotic and anxiolytic agent)

Potential applications

Treatment for schizophrenia and bipolar disorder, development of novel anti-cancer drugs

Need for further research

Yes, to fully understand potential applications and safety.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 59101-37-0 O-benzoyl-N-phenylacetyl-hydroxylamine 
• 55112-42-0 4-methylpiperazine-1-carbonyl chloride monohydrochloride 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

NOVEL PIPERIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR LIGANDS FOR TREATMENT OF DEPRESSION

Compounds of formula (I) wherein Ar1 and Q are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the treatme

Studies in Potential Filaricides: Part 19 - Synthesis of 1-Methyl-4-substituted Carbonylpiperazines as Diethylcarbamazine Analogs

The synthesis and antifilarial activity of a series of 1-methyl-4-substituted carbamoyl- and carbonylpiperazines (6 - 42) against Litomosoides carinii in cotton rats and Dipetalonema viteae in Mastomys natalensis are described.The most potent compound of this series, 1-methyl-4-(pyrrolidin-1-yl)carbonylpiperazine (7) causes 95 - 98 percent reduction of blood microfilarial count in cotton rats infected with L. carinii at an intraperitoneal or oral dose of 1.5 (base) or 3 (citrate) mg/kg given for 6 days.A number of other compounds also exhibit marked microfilaricidal efffect in the dose range of 6 - 30 mg/kg.