116830-29-6

Upstream product

• 1011296-23-3 (R)-2-[(S)-non-1-en-4-ylamino]-2-phenylethanol 
• 503822-33-1 (R)-2-(allylamino)-2-phenylethanol 
• 56613-80-0 D-2-phenylglycinol 
• 870138-25-3 (2R,4R)-3-allyl-2-pentyl-4-phenyloxazolidine 
• 116830-25-2 (3R,5S,7aS)-5-Pentyl-3-phenyl-hexahydro-pyrrolo[2,1-b]oxazole 

Relevant academic research and scientific papers

Access to optically pure nitrogen heterocycles based on hydrozirconation of unsaturated secondary amines

Optically active N-heterocycles with four-, five-, or six-membered rings can be prepared from unsaturated secondary amines, by using a one-pot hydrozirconation/iodination sequence as the key step. The presented method allows the preparation of 2-substituted pyrrolidines enantiomeric to those previously obtained from N-allyloxazolidines. The two approaches use the same reagents (allyl bromide and aldehydes) and the same (R)-2-phenyl-glycinol as the chiral inductor. Georg Thieme Verlag Stuttgart.

Stereoselective synthesis of pyrrolidines from N-allyl oxazolidines via hydrozirconation-cyclization

(Chemical Equation Presented) A new diastereoselective synthesis of pyrrolidines from readily available chiral N-allyl oxazolidines is presented. The construction of the pyrrolidine ring is achieved via a tandem hydrozirconation-stereoselective Lewis acid

ASYMMETRIC SYNTHESIS XIII SYNTHESIS OF 2-ALKYLPYRROLIDINES : TOWARDS AZABICYCLIC SYSTEMS

The enantiospecific synthesis of a series of 2(S)-alkylpirrolidines from 2-cyano oxazolopyrrolidine synthon 1 is described.Two of the synthesised compunds represent key intermediates towards azabicyclic alkaloids.