116830-34-3Relevant academic research and scientific papers
Asymmetric synthesis of 5-substituted pyrrolidinones via a chiral N-acyliminium equivalent
Baussanne, Isabelle,Chiaroni, Angele,Royer, Jacques
, p. 1219 - 1224 (2007/10/03)
5-Substituted pyrrolidinones 5 were synthesized in good yields and with fair to good diastereoselectivities from the chiral non-racemic oxazolopyrrolidinone 4. Various nucleophiles including cuprates, silanes and phosphites were used. The chiral induction
A simple stereoselective synthesis of enantiopure 2-substituted pyrrolidines and piperidines from chiral (R)-phenylglycinol-derived bicyclic 1,3-oxazolidines
Andres, Jose M.,Herraiz-Sierra, Ignacio,Pedrosa, Rafael,Perez-Encabo, Alfonso
, p. 1719 - 1726 (2007/10/03)
Chiral, nonracemic 2-substituted pyrrolidines and piperidines were prepared in high ee and moderate to good chemical yields in three steps from (R)-phenylglycinol and γ- or δ-chloroketones. The key step of the synthesis was the stereo- selective reductive ring-opening of chiral bicyclic 1,3- oxazolidines prepared by condensation of (R)-phenylglycinol and the corresponding ketones.
A Simple Asymmetric Synthesis of 2-Substituted Pyrrolidines and 5-Substituted Pyrrolidinones
Burgess, Laurence E.,Meyers, A. I.
, p. 1656 - 1662 (2007/10/02)
An efficient procedure for the preparation of the title compounds in high enantiomeric purity has been realized starting from 3-acylpropionic acids.Stereoselective reduction of chiral bicyclic lactams 2a-h, prepared from the corresponding γ-keto acid and
A Simple Asymmetric Synthesis of 2-Substituted Pyrrolidines from 3-Acylpropionic Acids
Meyers, A. I.,Burgess, Laurence E.
, p. 2294 - 2296 (2007/10/02)
The title compounds have been prepared from 3-acylpropionic acids 2 and (-)-R-phenylglycinol in a three-step sequence in >98percent enantiomeric excess.The R group in 2 ultimately becomes the 2-substituent in the chiral pyrrolidine.
ASYMMETRIC SYNTHESIS XIII SYNTHESIS OF 2-ALKYLPYRROLIDINES : TOWARDS AZABICYCLIC SYSTEMS
Arseniyadis , S.,Huang , P. Q.,Husson , H.-P.
, p. 631 - 634 (2007/10/02)
The enantiospecific synthesis of a series of 2(S)-alkylpirrolidines from 2-cyano oxazolopyrrolidine synthon 1 is described.Two of the synthesised compunds represent key intermediates towards azabicyclic alkaloids.
