116830-43-4Relevant academic research and scientific papers
Synthesis of Enantioenriched Pyrrolidines via Gold-Catalyzed Tandem Cycloisomerization/Hydrogenation of Chiral Homopropargyl Sulfonamides
Yu, Yong-Fei,Shu, Chao,Tan, Tong-De,Li, Long,Rafique, Shahid,Ye, Long-Wu
, p. 5178 - 5181 (2016)
A novel gold-catalyzed tandem cycloisomerization/hydrogenation of chiral homopropargyl sulfonamides has been developed. Various enantioenriched pyrrolidines can be obtained in excellent yields and excellent enantioselectivities by combination of chiral tert-butylsulfinimine chemistry with gold catalysis. Importantly, this represents the first example of a pyrrolidine synthesis from homopropargyl sulfonamide.
