116885-07-5Relevant academic research and scientific papers
Iminophosphorane-mediated Annelation of a Pyridine or Pyrimidine Ring into an Indole Ring: Synthesis of β-, γ-Carbolines and Pyrimidinoindole Derivatives
Molina, Pedro,Fresneda, Pilar M.
, p. 1819 - 1822 (2007/10/02)
A number of pyridoindole, pyridoindole,and pyrimidoindole derivatives have been prepared.Ethyl 3-(1-methylindol-3yl)-2-triphenylphosphoranylideneaminoprop-2-enoate (2) reacts with aromatic isothiocyanates to yield the corresponding 1-arylamino-3-ethoxycarbonyl-9-methylpyridoindoles .Similarly, the ethyl 3-(1-methylindol-2-yl)-2-triphenylphosphoranylideneaminoprop-2-enoate (10) under similar reaction conditions leads to 1-arylamino-3-ethoxycarbonyl-5-methylpyridoindole .Also, iminophosphoranes (2) and (10) react with carbon disulphide to give the 1-thioxopyridoindole (8) and 1-thioxopyridoindole (15) respectively.The reaction of the 3-formyl-1-phenyl-2-triphenylphosphoranylideneaminoindole (17) with isothiocyanates at room temperatures leads directly to 3-aryl-2,3-dihydro-2-oxo-9-phenylpyrimidoindoles .
