116913-51-0Relevant articles and documents
Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase
Shreder, Kevin R.,Cajica, Julia,Du, Lingling,Fraser, Allister,Hu, Yi,Kohno, Yasushi,Lin, Emme C.K.,Liu, Steve J.,Okerberg, Eric,Pham, Lan,Wu, Jiangyue,Kozarich, John W.
scheme or table, p. 4743 - 4746 (2010/05/02)
The hit-to-lead optimization of the HNE inhibitor 5-methyl-2-(2-phenoxy-pyridin-3-yl)-benzo[d][1,3]oxazin-4-one is described. A structure-activity relationship study that focused on the 5 and 7 benzoxazinone positions yielded the optimized 5-ethyl-7-metho
SERINE HYDROLASE INHIBITORS
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Page/Page column 62-63, (2008/06/13)
Provided herein are benzoxazinone compounds of formula (I) and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.