116943-69-2Relevant articles and documents
Synthesis of N-sulfamoyloxazolidinones and -perhydrooxazinones reactivity and use as donors in the Transsulfamoylation reaction; application to the preparation of 2-chloroethylnitrososulfamides. IV
Dewynter, Georges,Abdaoui, Mohamed,Regainia, Zine,Montero, Jean-Louis
, p. 14217 - 14224 (1996)
Starting from chlorosulfonyl isocyanate, successive addition of selected 1,2 and 1,3 haloalcohols, sulfamoylation with the nitrogen mustard and cyclization in alkaline conditions give title compounds in good yields. These sulfamoyloxazolidinones and sulfamoylperhydrooxazinones were revealed as efficient 2-chloroethylsulfamoyl donors in the 2-chloroethylnitrosulfamides synthesis; five new CENS (derived from heterocyclic amines and amino acids) were thus synthezised. According to the experimental conditions, N-sulfamoylcyclocarbamates can be reopened by nucleophiles giving addition products by transcarbamoylation.
Derives de l'isocyanate de chlorosulfonyle. Synthese, structure et activite biologique d'halogeno-2 ethoxycarbonylsulfamides
Agoh, Bernadette,Dewynter, Georges,Montero, Jean-Louis,Leydet, Alain,Imbach, Jean-Louis
, p. 867 - 872 (2007/10/02)
New 2-chloroethoxycarbonylsulfamides are synthesized in a two step reaction from C.S.I., haloethanol and various primary and secondary amines.Cyclization of these sulfamides in basic medium gives the corresponding sulfamyl-oxazolidinones.All structures are established by IR, NMR, MS and RX diffraction data.The antitumor activity of the products towards LI210 is reported.