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1169551-49-8

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1169551-49-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1169551-49-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,9,5,5 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1169551-49:
(9*1)+(8*1)+(7*6)+(6*9)+(5*5)+(4*5)+(3*1)+(2*4)+(1*9)=178
178 % 10 = 8
So 1169551-49-8 is a valid CAS Registry Number.

1169551-49-8Downstream Products

1169551-49-8Relevant articles and documents

The design, synthesis, and biological evaluation of PIM kinase inhibitors

Tsuhako, Amy Lew,Brown, David S.,Koltun, Elena S.,Aay, Naing,Arcalas, Arlyn,Chan, Vicky,Du, Hongwang,Engst, Stefan,Franzini, Maurizio,Galan, Adam,Huang, Ping,Johnston, Stuart,Kane, Brian,Kim, Moon H.,Douglas Laird,Lin, Rui,Mock, Lillian,Ngan, Iris,Pack, Michael,Stott, Gordon,Stout, Thomas J.,Yu, Peiwen,Zaharia, Cristiana,Zhang, Wentao,Zhou, Peiwen,Nuss, John M.,Kearney, Patrick C.,Xu, Wei

, p. 3732 - 3738 (2012/07/17)

A series of substituted benzofuropyrimidinones with pan-PIM activities and excellent selectivity against a panel of diverse kinases is described. Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitation. Using X-ray crystal structures of the bound PIM-1 complexes with 3, 5m, and 6d, we were able to guide the SAR and identify the alkyl benzofuropyrimidinone (6l) with good PIM potencies, permeability, and oral exposure.

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