1169707-29-2 Usage
General Description
The chemical "(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)-2-buten-1-one" is a complex organic compound with a long and specific chemical structure. It contains functional groups such as triazolopyrazine, amino, and phenylethyl, along with various fluorine-substituted aromatic rings. The compound has potential applications in the pharmaceutical industry, particularly in the development of novel drugs and biologically active molecules due to its unique structure and functional groups. Additionally, it can be used as a reference standard for analytical and research purposes in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1169707-29-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,9,7,0 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1169707-29:
(9*1)+(8*1)+(7*6)+(6*9)+(5*7)+(4*0)+(3*7)+(2*2)+(1*9)=182
182 % 10 = 2
So 1169707-29-2 is a valid CAS Registry Number.
1169707-29-2Relevant articles and documents
Practical and economical approach to synthesize sitagliptin
Lin, Kuaile,Cai, Zhengyan,Zhou, Weicheng
, p. 3281 - 3286 (2013)
Economic syntheses of sitagliptin phosphate monohydrate, acknowledged as the first dipeptidyl peptidase 4 (DPP-4) inhibitor, have been achieved in an overall yield of 42.4% in four steps from 1-{3-(trifluoromethyl)-5,6-dihydro-[1, 2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}-4-(2,4,5-trifluorophenyl)butane-1,3-dione. The key stereoselective reduction of this process was carried out by NaBH 4/HCOOH instead of expensive and toxic catalysts or ligands. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
PREPARATION OF SITAGLIPTIN AND SALTS THEREOF
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Page/Page column 17, (2011/04/14)
Processes for preparing sitagliptin and its pharmaceutically acceptable salts, and process intermediates.
