1169833-47-9

Upstream product

• 1169833-45-7 (3R,6S,7S,8R,8aS)-6-[(1-benzenesulfonyl-2-formyl-3-indolyl)-methyl]-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 1169833-48-0 (3R,6R,7S,8R,8aS)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 1169833-49-1 (3R,6S,7S,8R,8aS)-6-[(1-benzenesulfonyl-2-vinyl-3-indolyl)-methyl]-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 

Relevant academic research and scientific papers

A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-16-episilicine

(Chemical Equation Presented) Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group. 2009 American Chemical Society.

Enantioselective total synthesis of the indole alkaloid 16-episilicine

The first total synthesis of (-)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.