1169833-50-4Relevant academic research and scientific papers
A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-16-episilicine
Amat, Mercedes,Llor, Nuria,Checa, Begona,Molins, Elies,Bosch, Joan
body text, p. 178 - 189 (2010/04/04)
(Chemical Equation Presented) Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group. 2009 American Chemical Society.
Enantioselective total synthesis of the indole alkaloid 16-episilicine
Amat, Mercedes,Checa, Begona,Llor, Nuria,Molins, Elies,Bosch, Joan
supporting information; experimental part, p. 2935 - 2937 (2009/11/30)
The first total synthesis of (-)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.
