1169833-53-7

Upstream product

• 1169833-52-6 (4R,4aS,12aR)-7-(benzenesulfonyl)-4-ethyl-2-[(1R)-2-hydroxy-1-phenylethyl]-1,3,4,4a,5,6,12,12a-octahydropyrido[3',4':4,5]cyclohepta[1,2-b]indole 

Relevant academic research and scientific papers

A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-16-episilicine

(Chemical Equation Presented) Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group. 2009 American Chemical Society.

Enantioselective total synthesis of the indole alkaloid 16-episilicine

The first total synthesis of (-)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.