1169860-32-5Relevant academic research and scientific papers
Biomimetic chromanol cyclisation: A common route to a-tocotrienol and α-tocopherol
Chapelat, Julien,Chougnet, Antoinette,Woggon, Wolf-D.
experimental part, p. 2069 - 2076 (2009/09/08)
A common synthetic route to a-tocotrienol and a-tocopherol has been accomplished by a biomimetic cyclisation that yields the chromanol ring. The chirality at C2 of the chro- manol was induced by a covalently attached chiral dipeptide. Its terminal Asp participates in the enantioface-selective pro-tonation of the double bond of the a-tocotrienol precursor. a-Tocotrienol was diastereoselectively hydrogenated to a-tocopherol.
