116993-42-1

Basic information

• Product Name: ethyl 7-hydroxy-6-methyl-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate
• Synonyms: ethyl 7-hydroxy-6-methyl-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate;1,2,3,5-Tetrahydro-7-hydroxy-6-methyl-5-oxo-8-indolizinecarboxylic acid ethyl ester
• CAS NO: 116993-42-1
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.25
• Mol File: 116993-42-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.31
• CAS DataBase Reference: ethyl 7-hydroxy-6-methyl-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-hydroxy-6-methyl-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate(116993-42-1)
• EPA Substance Registry System: ethyl 7-hydroxy-6-methyl-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate(116993-42-1)

Safety Data

• Hazardous Substances Data: 116993-42-1(Hazardous Substances Data)

Usage

General Description

Ethyl 7-hydroxy-6-methyl-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate is a complex organic compound with a tetrahydroindolizine core. It contains an ethyl ester group, a hydroxy group, and a methyl group, along with a carbonyl group. This chemical compound has potential applications in pharmaceuticals, particularly in the development of new drugs. Its unique structure and functional groups make it a valuable precursor for the synthesis of various biologically active compounds. Its properties and potential uses make it an important target for chemical synthesis and research.

Upstream product

• 72130-68-8 ethyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydro-8-indolizinecarboxylate 
• 74-88-4 methyl iodide 
• 5264-35-7 2-methoxy-1-pyrroline 
• 16631-18-8 diethyl 2-methylacetonedicarboxylate 
• 58322-48-8 (E)-ethyl 3-oxo-2-(pyrrolidin-2-ylidene)butanoate 
• 15781-71-2 bis(2,4,6-trichlorophenyl) 2-methylmalonate 
• 25219-53-8 pyrrolidin-2-ylideneacetic acid ethyl ester 

Downstream Products

• 1150098-45-5 7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,3,5,1-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide 
• 1193487-43-2 7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 
• 1193487-42-1 7-(4-bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 
• 1193488-35-5 7-(4-Bromo-2-fluoro-phenylamino)-6-methyl-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carboxylic acid (2-vinyloxy-ethoxy)-amide 
• 1150098-34-2 7-(2-Fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-hydroxy-ethoxy)-amide 
• 1150098-37-5 7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 

Relevant articles and documents

Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy

The structure-based design, synthesis, and biological evaluation of two novel series of potent and selective MEK kinase inhibitors are described herein. The elaboration of a lead pyrrole derivative to a bicyclic dihydroindolone core provided compounds wit

MEK INHIBITOR SALTS AND SOLVATES THEREOF

The present invention relates to sodium salt forms of 7-(4-Bromo-2-fluoro- phenylamino)-6-methyl-5-oxo-1,3,5-tetrahydro-indolizine-8-carboxylic acid (2- hydroxyethoxy)-amide and 7-(4-Bromo-2-fluoro-phenylamino)-5-oxo- 1,2,3,5-tetrahydro- indolizine-8-carboxylic acid cyclopropylmethoxy-amide and their corresponding solvates and polymorphs, which are useful in the treatment of a disease, disorder or syndrome associated with MEK inhibition, such as cancer, in mammals.

MAPK/ERK KINASE INHIBITORS

Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.