116997-22-9

Basic information

• Product Name: 1H-imidazol-2-yl(4-methylphenyl)methanone
• Synonyms: 1H-Imidazol-2-yl(4-methylphenyl)methanone; methanone, 1H-imidazol-2-yl(4-methylphenyl)-
• CAS NO: 116997-22-9
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• Mol File: 116997-22-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 398.1°C at 760 mmHg
• Flash Point: 197.1°C
• Density: 1.198g/cm³
• Vapor Pressure: 1.52E-06mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 1H-imidazol-2-yl(4-methylphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-imidazol-2-yl(4-methylphenyl)methanone(116997-22-9)
• EPA Substance Registry System: 1H-imidazol-2-yl(4-methylphenyl)methanone(116997-22-9)

Safety Data

• Hazardous Substances Data: 116997-22-9(Hazardous Substances Data)

Usage

Structure

A ketone derivative with an imidazole ring and a 4-methylphenyl group

Type of compound

Chemical compound

Applications

Synthesis of pharmaceuticals and agrochemicals

Role in medicinal chemistry

Interacts with biological targets such as enzymes and receptors

Use in organic synthesis

Versatile building block for constructing complex molecular structures

Value

Valuable and versatile in the field of chemistry and life sciences

Upstream product

• 397329-13-4 2-[hydroxy(4-methylphenyl)methyl]-N,N-dimethyl-1H-imidazole-1-sulfonamide 
• 288-32-4 1H-imidazole 
• 874-60-2 4-methyl-benzoyl chloride 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 23230-39-9 1-[(dimethylamino)methyl]-imidazole 

Downstream Products

• 397329-17-8 methyl 5-chloro-2-{(1E)-3-[2-(4-methylbenzoyl)-1H-imidazol-1-yl]prop-1-enyl}benzoate 
• 1214718-66-7 ethyl 8-p-tolylimidazo[1,2-a]pyridine-7-carboxylate 
• 1214718-67-8 ethyl 6-methyl-8-p-tolylimidazo[1,2-a]pyridine-7-carboxylate 
• 397329-16-7 (1-Allyl-1H-imidazol-2-yl)[4-(methyl)phenyl]methanone 

Relevant articles and documents

Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators

In our search for new PPARα/γ agonists, we designed and synthesized a series of benzoylazole-based carboxylic acids. Compound 9 showed potent PPARγ partial agonistic activity with modest PPARα agonistic activity. The sodium salt of 9 (9Na) demonstrated po

NOVEL HETEROARYL DERIVATIVE

A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. (1) wherein: the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl, etc.

Pyrrole derivatives

Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 alkylene, etc.; Ar2 is an optionally substituted aryl, etc.; W2 and Ar1 mean the following (1) and (2): (1) W1 is an optionally substituted C1-C4 alkylene, etc.; Ar1 is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar1 is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.