116998-62-0

Basic information

• Product Name: 3-(2-ethoxyethoxy)aniline
• CAS NO: 116998-62-0
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.2316
• Mol File: 116998-62-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 313.6°C at 760 mmHg
• Flash Point: 156.7°C
• Density: 1.056g/cm³
• Vapor Pressure: 0.000492mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 3-(2-ethoxyethoxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-ethoxyethoxy)aniline(116998-62-0)
• EPA Substance Registry System: 3-(2-ethoxyethoxy)aniline(116998-62-0)

Safety Data

• Hazardous Substances Data: 116998-62-0(Hazardous Substances Data)

Upstream product

• 554-84-7 meta-nitrophenol 

Relevant articles and documents

Fine tuning of 4,6-bisphenyl-2-(3-alkoxyanilino)pyrimidine focusing on the activity-sensitive aminoalkoxy moiety for a therapeutically useful inhibitor of receptor for advanced glycation end products (RAGE)

Through the fine tuning of the activity-sensitive aminoalkoxy moiety of 4,6-bisphenyl-2-(3-alkoxyanilino)pyrimidine as a novel inhibitor of the receptor for advanced glycation end products (RAGE), the tertiary amine was elucidated as an essential part associated with RAGE inhibition. On the basis of this finding, a 3-(N,N-dimethylamino)pyrrolidine analog 12o was identified as a therapeutically useful RAGE inhibitor with improved activity and solubility. Molecular modeling studies predicted that the improved inhibitory activity is induced by additional hydrogen bonds between the nitrogen atom of the pyrrolidine ring and Arg48 and by an interaction between the dimethylamino-substituent of the pyrrolidine moiety and a relatively hydrophobic groove in the RAGE binding site.