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Relevant academic research and scientific papers

N-rich Porous Organic Polymer as Heterogeneous Organocatalyst for the One-Pot Synthesis of Polyhydroquinoline Derivatives through the Hantzsch Condensation Reaction

Incorporation of nitrogen functionality onto the high surface area porous polymeric network are very demanding in designing suitable heterogeneous organocatalyst having surface basicity. Here we report the synthesis of a new N-rich triazine based micropor

Solvent free, environment benign synthesis of 1,4-dihydropyridines and polyhydroquinolines by using heterogeneous Zn/MCM-41 catalyst

Heterogeneous catalysis has been utilized in number of efficient reactions with higher selectivity of the product, more stable, reusable and easy for separation as compared to homogeneous catalysts. Generally, heterogeneous catalysts are prepared by using mesoporous materials, microporous materials, metal oxides and metal organic framework. The mesoporous materials have small particle size and high surface area as compared to the microporous materials. The adsorbent mesoporous materials have highly efficient for the therapeutic applications in chemistry hence it has best as compared to other heterogeneous materials. Herein, we have reported synthesis of 1,4-dihydropyridines and polyhydroquinolines at solvent free and environmental benign condition in the presence of Zn/MCM-41 catalyst. The present protocol gives excellent yield (89–96%) of the product within short reaction time by easy work up procedure and no need of further purification of product. The catalyst was characterized by XRD diffractometer, SEM, EDAX, TGA-DTA, BET surface area analysis and FT-IR Spectroscopy. The synthesized organic compounds were characterized by FT-IR, 1H NMR, 13C NMR, LC–MS spectrometry. Graphical abstract: [Figure not available: see fulltext.]

New Copper Complex on Fe3O4 Nanoparticles as a Highly Efficient Reusable Nanocatalyst for Synthesis of Polyhydroquinolines in Water

Abstract: In this work, we present a simple, environmentally friendly and economical route for the preparation of a novel copper-Schiff-base organometallic complex on Fe3O4 nanoparticles (Fe3O4@Schiff-base-Cu) u

Melamine supported on hydroxyapatite-encapsulated-γ-Fe2O3: A novel superparamagnetic recyclable basic nanocatalyst for the synthesis of 1,4-dihydropyridines and polyhydroquinolines

In this paper, the preparation and characterization of hydroxyapatite-encapsulated γ-Fe2O3 nanoparticles functionalized with Melamine nanocomposite (γ-Fe2O3@HAp@Melamine) are presented. The resulting nanocomposite was characterized by infrared spectroscopy, scanning electron microscope, thermal gravimetric analysis, X-ray diffraction, vibrating sample magnetometer and elemental analysis. The catalytic activity of γ-Fe2O3@ HAp@Melamine as a magnetic powerful basic nanocatalyst was probed through one-pot synthesis of 1, 4-dihydropyridine and polyhydroquinoline derivatives through Hantzsch condensation reaction under solvent-free thermal conditions. The heterogeneous catalyst could be recovered easily by simple magnetic decantation and reused many times without significant loss of its catalytic activity.

Biological activities of eco-friendly synthesized hantzsch adducts

Fourteen Hantzsch adducts with different substituents at the C-4 position were synthesized through multicomponent reactions by using citric or lactic acid as catalysts. To the best of our knowledge, this is the first report on the synthesis of such a clas

FeF3 as a novel catalyst for the synthesis of polyhydroquinoline derivatives via unsymmetrical Hantzsch reaction

A facile and highly efficient one-pot synthesis of polyhydroquinoline derivatives is reported via four-component condensation reaction of aldehydes, β-keto compounds, active methylene compounds and ammonium acetate in the presence of FeF3 as a catalyst in ethanol at 75-80 °C. The method offers several advantages including high yields, short reaction time, simple work-up procedure and catalyst reusability for several runs. The higher catalytic activity of FeF3 ascribed due to its high acidity, thermal stability and water tolerance. The superiority of use of FeF3 to the current process is compared with other Lewis acids, Fe-salts, fluoride sources and insights of the origin of the efficiency are discussed.

Identification of dihydropyridines that reduce cellular tau levels

A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structur