1169983-42-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 126-81-8 dimedone 
• 3218-36-8 4-Phenylbenzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 1408382-23-9 i-butyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 
• 1394961-64-8 4-([1,1’-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Bismuth(III) bromide catalyzed synthesis of polyhydroquinoline derivatives via the Hantzsch reaction

Abstract Bismuth(III) bromide is an efficient catalyst for the one-pot multicomponent synthesis of polyhydroquinolines via the Hantzsch reaction. The mild reaction conditions, short reaction times, high yields, and the remarkably low toxicity of bismuth c

Synthesis, characterization and heterogeneous catalytic application of a nickel(II) Schiff base complex immobilized on MWCNTs for the Hantzsch four-component condensation

A nickel(II) Schiff base complex immobilized on multi-wall carbon nanotubes (MWCNTs) surface as a highly efficient heterogeneous catalyst was synthesized and characterized by IR, X-ray diffraction patterns, scanning electron microscopy, energy-dispersive

Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl aceto

Four-component synthesis of polyhydroquinolines under catalyst- and solvent-free conventional heating conditions: mechanistic studies

A convenient and environmentally friendly procedure for the synthesis of polyhydroquinolines via a one-pot, four component condensation of different aromatic aldehydes with dimedone, ethyl acetoacetate and ammonium acetate has been developed. Upon heating

Straightforward Hantzsch four- and three-component condensation in the presence of triphenyl(propyl-3-sulfonyl)phosphoniumtrifluoromethanesulfonate {[TPPSP]OTf} as a reusable and green mild ionic liquid catalyst

Triphenyl(propyl-3-sulfonyl)phosphoniumtrifluoromethanesulfonate {[TPPSP]OTf} as a reusable, green and benign ionic liquid catalyst has been used in the Hantzsch four-component (synthesis of polyhydroquinolines) and three-component (synthesis of acridines

Thermally reversible solidification of novel ionic liquid [im]HSO4 by self-nucleated rapid crystallization: Investigations of ionic conductivity, thermal properties, and catalytic activity

In recent years, the growing concern for the environment has triggered the search for new materials that meet the criteria for the preservation of natural habitats. Among these materials are ionic liquids, the new generation of which has contributed subst

Melamine supported on hydroxyapatite-encapsulated-γ-Fe2O3: A novel superparamagnetic recyclable basic nanocatalyst for the synthesis of 1,4-dihydropyridines and polyhydroquinolines

In this paper, the preparation and characterization of hydroxyapatite-encapsulated γ-Fe2O3 nanoparticles functionalized with Melamine nanocomposite (γ-Fe2O3@HAp@Melamine) are presented. The resulting nanocomposite was characterized by infrared spectroscopy, scanning electron microscope, thermal gravimetric analysis, X-ray diffraction, vibrating sample magnetometer and elemental analysis. The catalytic activity of γ-Fe2O3@ HAp@Melamine as a magnetic powerful basic nanocatalyst was probed through one-pot synthesis of 1, 4-dihydropyridine and polyhydroquinoline derivatives through Hantzsch condensation reaction under solvent-free thermal conditions. The heterogeneous catalyst could be recovered easily by simple magnetic decantation and reused many times without significant loss of its catalytic activity.

Novel ionic liquid [2-Eim] HSO4 as a dual catalytic-solvent system for preparation of hexahydroquinolines under green conditions

A novel Bronsted acidic ionic liquid 2-ethylimidazolium hydrogen sulfate, [2-Eim] HSO4, was synthesized. Its structure was investigated using FT-IR, 1H NMR, 13C NMR, UV, TGA and DTA spectroscopy. This ionic liquid was util

Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ2/Smad inhibitors

Targeting TGFβ2/Smad signaling is an attractive strategy for several therapeutic applications given its role as a key player in many pathologies, including cancer, autoimmune diseases and fibrosis. The class of b-annelated 1,4-dihydropyridines (DHPs) repr

Synthesis of the first nano ionic liquid 1-methylimidazolium trinitromethanide {[HMIM]C(NO2)3} and its catalytic use for Hanztsch four-component condensation

A novel, green and reusable nano ionic liquid and catalyst, namely 1-methylimidazolium trinitromethanide {[HMIM]C(NO2)3}, was designed and fully characterized by 1H NMR, 13C NMR, IR, mass, X-ray diffraction patt