1170035-72-9Relevant academic research and scientific papers
Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase
Cavalli, Andrea,Lizzi, Federica,Bongarzone, Salvatore,Brun, Reto,Luise Krauth-Siegel,Bolognesi, Maria Laura
supporting information; experimental part, p. 3031 - 3035 (2010/03/31)
Novel quinazoline-type compounds were designed as inhibitors of the parasite specific enzyme trypanothione reductase (TR), and their biological activities were evaluated. Some of our compounds inhibited TR, showed selectivity for TR over human glutathione
