1170045-89-2Relevant academic research and scientific papers
Isocombretastatins A versus combretastatins A: The forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent
Messaoudi, Samir,Tréguier, Bret,Hamze, Abdallah,Provot, Olivier,Peyrat, Jean-Fran?ois,De Losada, Jordi Rodrigo,Liu, Jian-Miao,Bignon, Jér?me,Wdzieczak-Bakala, Joanna,Thoret, Sylviane,Dubois, Joelle,Brion, Jean-Daniel,Alami, Mouad
supporting information; experimental part, p. 4538 - 4542 (2010/02/17)
Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize
