1170046-00-0Relevant articles and documents
Isocombretastatins A versus combretastatins A: The forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent
Messaoudi, Samir,Tréguier, Bret,Hamze, Abdallah,Provot, Olivier,Peyrat, Jean-Fran?ois,De Losada, Jordi Rodrigo,Liu, Jian-Miao,Bignon, Jér?me,Wdzieczak-Bakala, Joanna,Thoret, Sylviane,Dubois, Joelle,Brion, Jean-Daniel,Alami, Mouad
, p. 4538 - 4542 (2009)
Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize