1170086-85-7

Basic information

• Product Name: C₁₆H₁₀ClNO₃
• Synonyms: C₁₆H₁₀ClNO₃
• CAS NO: 1170086-85-7
• Molecular Weight: 299.713
• Mol File: 1170086-85-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₀ClNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₀ClNO₃(1170086-85-7)
• EPA Substance Registry System: C₁₆H₁₀ClNO₃(1170086-85-7)

Safety Data

• Hazardous Substances Data: 1170086-85-7(Hazardous Substances Data)

Upstream product

• 108-43-0 3-monochlorophenol 
• 13031-39-5 3-chlorophenyl acetate 
• 69155-79-9 7-chloro-4-oxo-4H-benzopyran-3-carbaldehyde 
• 6921-66-0 4-chloro-2-hydroxy acetophenone 

Downstream Products

• 1170086-94-8 7-chloro-4-oxo-4H-chromene-3-carbothioic acid N-phenylamide 

Relevant articles and documents

3-Formylchromone based topoisomerase IIα inhibitors: Discovery of potent leads

Substituted 3-formylchromones were synthesized and evaluated as inhibitors of the human DNA topoisomerase IIα (hTopo-IIα) enzyme. The results of the decatenation, relaxation and DNA intercalation assays revealed that the compounds (11b, 12a, 12b, 12d, 12e, 13a and 13b) exhibited potent inhibitory activity against the hTopo-IIα enzyme, and are nonintercalating agents. These compounds also possess significant in vitro cytotoxicity (LC50 ranges from 0.5-8.6 μM) against prostate (PC-3) cancerous cell line as seen in comparison to the standard drug etoposide. To further probe the plausible mode of action of 3-formylchromone derivatives, molecular docking studies have also been carried out, which showed that the compounds under investigation fitted well in the ATP binding pocket of hTopo-IIα enzyme with good docking scores and form nonbonding interactions with the crucial residues of the catalytic site. The Royal Society of Chemistry.