1170086-95-9

Basic information

• Product Name: 6,7-dichloro-4-oxo-4H-chromene-3-carbothioic acid N-phenylamide
• Synonyms: 6,7-dichloro-4-oxo-4H-chromene-3-carbothioic acid N-phenylamide
• CAS NO: 1170086-95-9
• Molecular Weight: 350.225
• Mol File: 1170086-95-9.mol

Chemical Properties

• CAS DataBase Reference: 6,7-dichloro-4-oxo-4H-chromene-3-carbothioic acid N-phenylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dichloro-4-oxo-4H-chromene-3-carbothioic acid N-phenylamide(1170086-95-9)
• EPA Substance Registry System: 6,7-dichloro-4-oxo-4H-chromene-3-carbothioic acid N-phenylamide(1170086-95-9)

Safety Data

• Hazardous Substances Data: 1170086-95-9(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 1170086-86-8 C₁₆H₉Cl₂NO₃ 

Relevant articles and documents

Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation

6/6,7-Substituted 3-formylchromones (9a-e) react with 2 equivalents of 2-phenyl-4-dimethylamino-1-thia-3-azabuta-1,3-diene (10) or thiobenzamide (11) in refluxing toluene to furnish novel substituted 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones (12

Unusual transformations of 3-thiocarbamoylchromones

The reaction of malononitrile with 3-thiocarbamoylchromones was accompanied by rearrangement, resulting in the formation of 2,5-dihydro-1H-chromeno[2,3-b]pyridine-3-carbonitriles or 2-imino-5-oxo-1-phenyl-2,5-dihydro-1H-chromeno[2,3-b]pyridine-3-carbothio

Cytotoxic activity of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides

6/6,7-Substituted-3-formylchromones (8a-g) were reacted with 2 equivalents thiobenzamide (9) in refluxing toluene to furnish substituted-3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones (10a-g) in high yields. Similarly, when substituted-2-anilino-3-formylchromones (8a-d) were reacted with thiobenzamide (9, 2 equivalents) in refluxing xylene, 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides (11a-d) were obtained in high yields. All the compounds (10a-g) and (11a-d) display significant cytotoxic activity against a number of human cancer cell lines. Among these compounds 10e (IC50?=?10?μM), 10b (IC50?=?14.6?μM) and 10a (IC50?=?10.5?μM) showed maximum cytotoxic activity on neuroblastoma. Also, the compound 10c (IC50?=?10.5?μM) showed maximum cytotoxic activity on ovarian cancer cell line.